Argireline (Acetyl Hexapeptide-8)

What it is

Argireline (acetyl hexapeptide-8) is a topical cosmetic peptide marketed as a needle-free alternative to neuromodulators for softening expression lines, the wrinkles that form where facial muscles repeatedly contract. A hexapeptide is a chain of six amino acids.

In the PeptidesAI encyclopedia it is categorized under skin and anti-aging. It was identified through a rational design program aimed at finding non-toxic molecules that mimic the action of botulinum neurotoxins, and it is regulated as a cosmetic ingredient.

How it's thought to work

Argireline mimics part of SNAP-25, a protein involved in neurotransmitter release, and is described as mildly interfering with neurotransmitter release at the neuromuscular junction, which reduces the fine muscle contractions that create expression lines. In laboratory work, it inhibited neurotransmitter release by interfering with the formation or stability of the SNARE complex, the protein complex that drives the vesicle fusion needed for release. That study reported much lower efficacy than botulinum neurotoxin.

What the research says

Cosmetic studies show a measurable but modest reduction in wrinkle depth. In the paper that first described it, an emulsion containing the peptide reduced wrinkle depth by up to 30% over 30 days of treatment in healthy women volunteers. In a later randomized, placebo-controlled study of 60 people in China with peri-orbital wrinkles, the subjective total anti-wrinkle efficacy after 4 weeks was reported as 48.9% for argireline versus 0% for placebo, with roughness measures decreasing in the argireline group. Argireline is regulated as a cosmetic ingredient.

Reported side effects

Occasional mild irritation of the skin has been reported. In the original study it did not show primary skin irritation. Its effects are far subtler than those of injectable neuromodulators.

Form

Argireline is used in pre-formulated topical serums and creams, so it is not reconstituted.

Important notes

Argireline is a topical cosmetic ingredient only and is not intended for injection. Reconstitution does not apply to it.

Sources

1. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Blanes-Mira C et al. Int J Cosmet Sci, 2002. Preclinical
2. The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. Wang Y et al. Am J Clin Dermatol, 2013. Human trial

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Frequently asked questions

These questions cover the same ground as the sections above, in a shorter format.

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